
NewAnesthesiology (PubMed)··Systematic Review
Pain scores alone can miss how postoperative pain limits movement and daily activity. This review focused on functional interference and suggests a measurable benefit from selective COX-2 inhibitors while preserving uncertainty around longer-term outcomes and uncommon harms.
Med-SurgAcross 38 randomized trials with 5,424 participants, selective COX-2 inhibitors reduced acute pain interference by 1.1 points on a 0-to-10 Brief Pain Inventory scale, meeting the review's 1-point threshold for minimal clinical importance. Evidence certainty for this outcome was moderate.
Key takeaways
- The acute pain-interference estimate was based on seven trials and favored selective COX-2 inhibitors (mean difference -1.1, 95% CI -1.4 to -0.8).
- Chronic pain incidence was lower in five trials, but certainty was low; chronic pain intensity was not significantly different in the single trial reporting it.
- Quality of recovery improved slightly with low-certainty evidence, and the review found no differences in the other reported adverse events.
Why this matters on shift
Pain scores alone can miss how postoperative pain limits movement and daily activity. This review focused on functional interference and suggests a measurable benefit from selective COX-2 inhibitors while preserving uncertainty around longer-term outcomes and uncommon harms.
Bedside takeaway
Pair pain scores with functional assessment and monitor response within the ordered multimodal analgesia plan.
Nursing implications
- Assess both pain intensity and pain-related function after surgery, and monitor medication response and contraindications according to the ordered multimodal analgesia plan and local protocol.
Limitations & cautions
- Abstract-only summary. Chronic pain, quality-of-recovery, and adverse-event findings were supported by low- or very-low-certainty evidence, and the abstract does not describe results by specific drug, dose, or operation.
- AI-summarized from the linked source. Review the original article before applying to practice.
Citations · exact source links
AI-summarized from the linked source. Review the original article before applying to practice.




